Relationship between estrogen and cholesterol

Estrogen & The Heart | Cleveland Clinic

relationship between estrogen and cholesterol

Expert: Jumps in cholesterol reported in the study could have an impact on More research on the connection between menopause and heart. J Pharmacol Exp Ther. Jul;(1) An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in. An Investigation of the Relationship Between Estrogen,. Estrogen Metabolites and Blood Cholesterol Levels in. Ovariectomized Rats. DONGFANG LIU and.

When estrogen levels decline, levels of LDL cholesterol the harmful kind increase, and levels of HDL cholesterol the positive kind decrease, leading to the build up of fat and cholesterol in the arteries that contributes to heart attack and stroke. It made sense that replacing estrogen through HRT would potentially improve heart health.

This thinking contributed to a huge rise in the number of women being prescribed estrogen.

Estrogen & High Cholesterol

Rethinking old ideas Recent studies on the long-term use of HRT are changing that way of thinking. With scientific data potentially linking HRT to higher risks of heart attack, stroke and other serious health problems, many women are reconsidering HRT. This study of more than 2, women with existing coronary heart disease was designed to test whether estrogen plus progestin would prevent a second heart attack. During the first year of HRT, women in the study had a 50 percent increase in heart attack and stroke.

relationship between estrogen and cholesterol

But, after two years of treatment, women on HRT actually had less heart disease and fewer heart attacks and strokes compared with women not taking HRT. The study left many unanswered questions, leading researchers to take another look at these same women.

They published their results in Early data from this group of women showed that HRT significantly increased the risk of breast cancer, heart attack, stroke and blood clots in the legs and lungs.

The effects of estradiol on blood lipids and lipoproteins in postmenopausal women.

Then, inthe NIH stopped the estrogen-only study arm, in which women who had undergone hysterectomy were taking estrogen. Data showed that estrogen increased their risk of blood clots and stroke and did not reduce the risk of heart attack. A change in recommendations These studies were the first large-scale trials that looked for cause and effect with heart disease and HRT. HRT does offer some benefits, such as preventing osteoporosis and reducing the risk of colon cancer.

But the data on heart-related risks from these studies were very compelling. As a result, the American Heart Association and the U.

The effects of estradiol on blood lipids and lipoproteins in postmenopausal women.

HRT should not be used for prevention of heart attack or stroke. Use of HRT for other problems such as preventing osteoporosis should be carefully considered and the risks weighed against the benefits.

High Cholesterol Levels Cholesterol is a waxy substance that is produced by the liver and also ingested with certain foods, according to KidsHealth. Cholesterol is required by the body to make vitamin D after the skin is exposed to UV light from the sun and to produce some hormones, build cell walls and help you digest fats.

Your liver produces enough cholesterol to meet the needs of your body every day. Cholesterol is also found in foods that originate from animal sources, such as meat, eggs and whole-fat dairy products.

  • Menopause and Heart Disease
  • Estrogen & Hormones

High levels of cholesterol in the blood stream can increase your risk of coronary artery disease, cardiovascular disease, stroke and heart attack. Some of the factors that lead to high cholesterol are obesity, gender, heredity, diet and age.

relationship between estrogen and cholesterol

Relationship Between Estrogen and Cholesterol Physicians at the Mayo Clinic state that declining estrogen levels during menopause and peri-menopause can lead to an increase in LDL cholesterol, commonly called "bad" cholesterol. This increase in the bad cholesterol and concurrent decrease in HDL cholesterol, or the "good" cholesterol, increases the risk of heart disease.

Estrogen appears to have a protective effect on the vasculature of the body against diseases. Estrogen stimulates the release of nitric oxide and decreases the contraction of smooth muscle cells. This relationship appears to reduce the risk of high blood pressure and high cholesterol levels while estrogen levels remain high during a woman's childbearing years.